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Of note, enhanced risk of multiple sclerosis has been associated with variations in the circadian genes ARNTL/BMAL1 and CLOCK ( Does an intrinsic circadian rhythm indwell the Schwann cells

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Temperature fluctuations, freeze-thaw cycles, shaking, and high concentrations all promote aggregation

[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations