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CYP3A4 inhibition by ketoconazole yielded an IC 50 of 0.83 M in iHLOs, comparable to HepaRG cells (0.42 M) but less potent than the IC 50 (0.056 M) from PHHs, demonstrating their applicability for studying CYP-mediated drug-drug interactions (Fig
In comparison, fermentation methods usually yield around 10 g/L and produce a complex mixture of cellular metabolites, proteins, and by-products
Clean and Vegan Positioning: There is a strong shift towards vegan, cruelty-free, and "clean" formulations to meet modern ethical consumer standards
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