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Under mechanical stimulation from exercise, increased irisin levels facilitate the removal of excess iron ions from bone cells, thereby preventing ferroptosis and preserving bone structural integrity

Oxidative stress and diabetes mellitus

Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

The tonicity of an aqueous solution of the water-soluble composition of the present invention should be within the tolerable range when administered and is adjusted, for example, by isotonizing agents such as sodium chloride and mannitol