does metformin work like semaglutide Do You Still Need If You Take a GLP-1 for Diabetes? Semaglutide vs. Metformin vs. Tirzepatide:

A case report published in Physiological Reports (PMID 36303408) documented that co-administration of MK-677 and LGD-4033 in a 25-year-old male produced measurable increases in lean body mass (+3.1% trunk lean) alongside significant lipid and hepatic biomarker disruption, underscoring the importance of controlled research conditions when investigating sustained GHS-R1a stimulation

We still dont know what a lifetime on GLP-1s looks like, The New York Times said

May 2016;101(5):2076-2083

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