GCL is specific for the glutamyl moiety and is regulated physiologically by: (a) non-allosteric feedback competitive inhibition by GSH (Ki=2.3mM), which involves binding of GSH to the glutamate and another site on the enzyme [8, 9] and (b) availability of its precursor, cysteine [1] .The apparent Km values of GCL for glutamate is 1.8 mM, and for cysteine and 0.10.3 mM [9]
[2] Once administered intramuscularly, B12 is gradually released into the bloodstream and transported to the liver, where approximately half of the body's total B12 stores are held
Professor Gary Wittert, Adelaide University chair of medicine, told Fairfax Media this week: ''I wish we had pushed the issue much harder at the time
Serious and rarer side effects can include muscle cramping, irregular heartbeat, shortness of breath, slurred speech, vision changes, chest pain and weakness on one side of the body