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The pivotal trial randomized 412 HIV-infected patients with abdominal fat accumulation to 2 mg of subcutaneous tesamorelin daily or placebo for 26 weeks, in a double-blind, placebo-controlled design

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721 A comprehensive nutrition study found that iron intake increased ischemic stroke mortality in Japanese men, 722 and higher serum ferritin levels were linked to a higher risk of ischemic stroke in type 2 diabetes patients and postmenopausal women, 723,724 suggesting that peripheral iron accumulation is a risk factor for ischemic stroke

These findings confirm the presence of a unique bioenergetic inefficiency