glp 1 drug tirzepatide Researchers move closer to matching patients with GLP-1 that works best for them which glp 1 drugs are

The TRIUMPH 4 trial specifically enrolled adults with obesity or overweight who also had knee osteoarthritis

10.1007/s13311-013-0177-6 148 EnriquezJ

Additionally, no alternative medications to semaglutide will be discussed, as this article is centered on understanding semaglutide and topiramate

Interestingly, GLP-1 is also known to decrease the rewarding effects of food intake by interacting with parts of the mesolimbic dopamine system such as the ventral tegmental area (VTA), nucleus accumbens (NAc) [34], and also GABAergic circuits in the laterodorsal tegmental nucleus (LDTg) [35], which makes brain GLP-1R signaling a promising target for the treatment of alcohol and cocaine abuse disorders [36, 37]