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However, efforts must also focus on the interim strategy to slow neuron losses in brain structures impacted including neocortices, hippocampus, locus ceruleus and the nucleus basalis of Meynert by stimulating synaptogenesis, neurogenesis and reducing neuroinflammation and oxidative stress

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Succinyl-CoA is also generated as a product of propionyl-CoA metabolism, a substrate formed from the oxidative metabolism of isoleucine and valine, from propionate from gut flora, from odd-chain fatty acid (OC-FA) metabolism, and from metabolism of methionine and threonine in the form of -ketobutyrate (-KB)

R., Smiley, A., & Saadabadi, A