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A prospective randomized controlled study

doi: 10.1182/blood-2016-10-569186 77

Key outcomes include significant reductions in body weight, increases in the number of granulosa cell layers, and the presence of oocytes within follicles ( 2.1 Regulation of glucose metabolism-related signaling pathways Silent information regulator 1 (SIRT1) a nicotinamide adenine dinucleotide (NAD + )-dependent deacetylase, catalyzes the deacetylation of histone and non-histone proteins, exerting pleiotropic effects on endocrine and metabolic regulation, immune responses, oxidative stress mitigation, inflammatory pathways, and aging ( Studies have demonstrated that resveratrol may activate and upregulate NAD + -dependent SIRT1 which binds to the forkhead box transcription factors O1 (FOXO1), FOXO3a, and FOXO4, specifically deacetylating these proteins ( + levels by stimulating its synthesis, subsequently activating SIRT1 and various downstream effectors ( Resveratrols glucoregulatory properties extend to the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) pathway, a central mediator of insulin signaling in IR ( In conclusion, the therapeutic effects of resveratrol in ameliorating glucose metabolism abnormalities in PCOS through multi-pathway synergy rather than isolated mechanisms