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GLP-1 agonists can trigger acute kidney injury in dehydrated states and pose thyroid considerations

Patients should maintain their usual eating patterns on the first day unless otherwise instructed by their healthcare provider

doi: 10.1073/pnas.2309967120

Adverse reactions and tolerability: Since they are administered via injection and affect gastric emptying (particularly in the case of shorter-acting agents), GLP-1 receptor agonists present some tolerability concerns