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Description

Activated Caspase-3 cleaves gasdermin E (GSDME), releasing its N-terminal pore-forming domain (PFD) from the C-terminal inhibitory structure, thereby forming membrane pores and inducing GSDME-mediated pyroptosis (46)

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These findings underscore the importance of early intervention targeting metabolic alterations to prevent long-term cardiac consequences in TTS

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Recommendations and future directions: The 2024 American Diabetes Association guidelines recommend patients with type 2 diabetes have a comprehensive eye exam at the time of diagnosis and annually thereafter

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