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The principal mechanism driving AOPPs generation involves the activated myeloperoxidase-H 2 O 2 -chloride system in neutrophils, with myeloperoxidase serving as the sole enzyme capable of generating chlorinated oxidants (Figure 2) (72, 73)

In situ hybridization initially revealed pancreatic GLP-1R mRNA only in the cells (12, 53, 116) but this may have been due to the lower level in the exocrine pancreas