EXTENDED DOSING INTERVALS AS A DRIVER FOR IMPROVED SUSTAINABILITY Native GLP-1 has a half-life that is measured in mere minutes6 and, as such, has limited therapeutic relevance without continuous dosing
As well as from poor diet and digestion, vitamin B12 deficiencies can also be affected by a genetic condition such as: o Pernicious anaemia o Crohns disease o Treatment with proton-pump inhibitors o Atrophic gastritis o Coeliac disease o Use of antacids (acid is required to release B12 from food) o Gastrointestinal surgery o Use of certain medications o Use of illegal drugs and substances including nitrous oxide
In phase 1b and 2 studies, pharmacokinetic assessments showed a mean elimination half-life of approximately 6 days, supporting once-weekly dosing and stable steady-state exposure after 46 weeks
AUTHORS CONTRIBUTIONS All authors contributed greatly to the success of this work CONFLICT OF INTEREST No conflict of interest to declare in this manuscript ACKNOWLEDGEMENT This case was carried out without direct funding, and the authors would like to thank the Head and the entire staffs of the Department of Human Physiology, College of Medical Sciences, Ahmadu Bello University, Zaria, for their support and provision of necessary facilities
