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For tretinoin/niacinamide topical alone: Apply to dried skin at night, followed by moisturizer if needed

Such chronic inflammation further worsens neuronal damage and reduces neurotrophic support, reflected by decreased brain-derived neurotrophic factor (BDNF) levels, contributing to the neuronal loss and behavioral abnormalities observed in ASD pathology (Azman and Zakaria 2022)

Spontaneous scratch-like lesions may be seen on the face or elsewhere