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Manufacturers quickly recognized that formulary tier placement drove prescription volume, and the implicit negotiation between PBMs and manufacturers over what price concession would secure preferred placement was already underway before the term rebate became standard industry language

HIV protease inhibitorsritonavir, indinavir, saquinavir, nelfinavir, and zidovudinewere described as ABCC1 substrate [35], suggesting that the overexpression of ABCC1 in infected cells makes these cells more resistant to chemotherapy

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