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To illustrate the conceptual framework and hypothesized mechanisms underlying this approach, we present a graphical summary (Figure 1) outlining the pathophysiological processes of cerebral ischemia, the pharmacological effects of SIN, and its potential delivery via the bone-brain axis

These timelines represent a general pattern, not a guarantee

Figures 2 and 3 are drawn using Figdraw ( Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest

Human endocrine studies involving related compounds have reported measurable increases in circulating growth hormone and insulin-like growth factor 1 biomarkers during supervised clinical investigations