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Therefore, lean mass preservation should be conceptualized as a parallel treatment target achieved through nutritional and behavioral strategies rather than pharmacology alone

However, while KATP channels are expressed in all GE neurons, only approximately half of VMH GE neurons express glucokinase, and approximately 30% express GLUT2 [78]

Semaglutide should be discontinued at least 2 months before planned pregnancy, whilst topiramate is now contraindicated for migraine prophylaxis in women of childbearing potential unless a Pregnancy Prevention Programme is followed with highly effective contraception

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