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In general, these hypotheses present the assumption that microbiota of proper composition regulates epithelial barrier function, including by regulating barrier permeability and TJ, influencing vascular permeability and angiogenesis, and affecting local inflammation and GALT tolerance [1, 55, 56]

Active secretion begins at the blastocyst stage, enabling hCG detection in the maternal circulation approximately 10 days after fertilisation, with the highest values reached between the 10th and 11th week of pregnancy before declining through the remainder of the first trimester

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