Not uncommonly, patients have other comorbid disorders, including depression, anxiety, and potentially neuroendocrine disturbances
In a photoaging study with a facial cream presented at a dermatology conference, improvements in skin density and strength, fine lines and skin firmness were reported in about 71 women over 12 weeks (Leyden et al., 2002, cited in Pickart et al., 2015)
They add that as immunotherapies are being more commonly utilized as first- and second-line treatments, immunotoxicity and autoimmunity are emerging as the Achilles heel of immunotherapy. In their Cancer Immunology Research paper, Bluestone and colleagues briefly discuss immunotherapeutic strategies that can potentially prevent irAEs, such as targeting intratumoral T cells directly, using bispecific antibodies to enhance localized targeting of tumor, and using engineered cell therapies to fine-tune immune cell responses
Retatrutide clinical trials also noted these effects were dose-dependent, meaning a gradual dose increase might help mitigate discomfort for future users
