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In addition, extensive study of neoplastic tissues by 5UTR CG-methylated islands analysis show the inactivation of the GSTP1, due to the hypermethylation

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(29), which in turn affects the systemic immune and inflammatory status, and has a significant impact on the progression of disease (30)

Tirzepatide also suppresses glucagon secretion, slows gastric emptying, and reduces appetite through central nervous system pathways, contributing to both glycaemic control and weight reduction