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Whole Cell Biosensors The simplest whole cell biosensor (WCB) functions as a traditional reporter assay (Figure 23B)

Second, we provide a systematic and updated overview of glial contributions, highlighting emerging evidence that microglia act as primary drivers of iron-mediated neurotoxicity, and that astrocytes undergo dynamic phenotypic shifts regulated by pathways such as mTOR and CSE/YAP/FOXD3 mechanisms that modulate neuronal vulnerability in previously underappreciated ways

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