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Salehi B, Berkay Ylmaz Y, Antika G, Boyunegmez Tumer T, Fawzi Mahomoodally M, Lobine D, Akram M, Riaz M, Capanoglu E, Sharopov F, Martins N, Cho WC, Sharifi-Rad J. Insights on the Use of -Lipoic Acid for Therapeutic Purposes. Biomolecules. 2019 Aug 9;9(8):356. doi: 10.3390/biom9080356. PMID: 31405030; PMCID: PMC6723188
This distribution largely corresponds to reported literature prevalence of 25%80% for UM-A, 10%50% for UM-B, and 10%25% for UM-0 (60)
A future challenge is to identify highly selective and potent, small-molecule drugs capable of activating CaMKK2 in the brain, which can then be validated preclinically in human induced pluripotent stem cell (iPSC) and animal models of bipolar disorder
Both groups reached the same maintenance dose, but the escalated group achieved greater weight loss (-17.1% vs -15.7%) with fewer gastrointestinal adverse events
