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Phytomedicine 12, 155162

Therefore, since the NRF-2 protein is not exposed to KEAP1, it can adopt a translocation to the nucleus and join genetic regions that have detoxifying enzymes as an end product (e.g., NADPH, glutathione peroxidase, ferritin, and heme oxygenase-1) or antioxidant proteins [16,2224]

10.1016/j.scitotenv.2023.166003 220 JinY.ChiJ.LoMonacoK.BoonA.GuH

These insights hold significant value in enhancing our comprehension of disease mechanisms and informing the development of novel therapeutic strategies (Fig