Contact your GP or healthcare provider if you experience: Severe or worsening joint pain that interferes with daily activities or does not improve with simple measures Joint swelling, redness, or warmth , which may indicate inflammation or infection Sudden onset of intense pain in a single joint, particularly if accompanied by fever (may require same-day assessment to exclude septic arthritis or gout) Joint pain associated with systemic symptoms such as unexplained fever, weight loss (beyond expected treatment effects), rash, or general malaise Persistent pain lasting more than two weeks despite self-care measures Joint stiffness lasting more than 30 minutes after waking , which may suggest inflammatory arthritis Reduced range of motion or inability to bear weight on affected joints Seek urgent medical attention (contact 111 or attend A&E) if: Joint pain is accompanied by severe abdominal pain, persistent vomiting, or signs of pancreatitis (if pancreatitis is suspected, stop your GLP-1 medication immediately
If you are on metformin for gestational diabetes management, both semaglutide and metformin and tirzepatide and metformin can be taken together safely
GLP-1 receptor agonists slow gastrointestinal motility throughout the digestive tract, prolonging transit time and allowing more water absorption from stool in the colon
37% falsely suggested FDA approval, while 14% failed to clarify they were offering compounded versions
