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The prospective studies included in the meta-analysis showed that in unsupplemented patients with ESRD, an increase of 5 mmol/L in homocysteine concentration is associated with an increase of 7% in the risk of total mortality and an increase of 9% in the risk of cardiovascular events [10]

However, this hypothesis lacks strong clinical evidence, and individual preference should guide timing decisions

doi:10.1161/STROKEAHA.114.008022

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