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Many perimenopausal women may benefit from both treatmentsHRT for menopausal symptoms and Wegovy for weight managementwith individualised assessment and regular review by your GP or specialist

Gradual discontinuation is generally preferred over sudden cessation to minimise adverse effects and allow for better adaptation

Native GLP-1 has an extremely short half-life due to rapid degradation by dipeptidyl peptidase-4 (DPP-4), and GLP-1 receptor agonist analogues are engineered with structural modifications to confer resistance to enzymatic cleavage and extend circulating activity in experimental systems

If you have concerns about continuing Wegovy during antibiotic treatment, discuss this with your prescriber rather than stopping medication independently