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To determine the specific location of the gastrointestinal (GI) tract where metformin regulates glucose metabolism, the entire GI tract of mice was subjected to autoradiography using 18 F-FDG as a glucose tracer

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Retatrutide produced 24.2% average weight loss at 48 weeks through triple receptor agonism (GIP/GLP-1/Glucagon), while Survodutide achieved 14.9-18.7% weight loss at 46 weeks through dual receptor agonism (GLP-1/Glucagon)

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Free Radic Biol Med 187:158170

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