Cardiac arrest Only in selected cases (prolonged arrest, known acidosis) Routes of Administration Intravenous sodium bicarbonate (acute/severe cases) Oral bicarbonate (chronic metabolic acidosis, CKD) Adverse Effects Metabolic alkalosis Hypokalemia Hypernatremia Fluid overload (especially in heart or renal failure) Paradoxical intracellular acidosis Reduced oxygen delivery (left shift of oxyhemoglobin curve) Contraindications / Cautions Respiratory acidosis Metabolic alkalosis Hypocalcemia Congestive heart failure Renal impairment (risk of sodium overload) Bicarbonate in AcidBase Disorders Low Bicarbonate Metabolic acidosis DKA Diarrhea Renal tubular acidosis Lactic acidosis High Bicarbonate Metabolic alkalosis Vomiting Diuretic use Excess bicarbonate intake Primary extracellular buffer Normal range: 2228 mmol/L Treats metabolic acidosis and hyperkalemia Overuse metabolic alkalosis Not routinely used in DKA unless severe acidosis Summary Bicarbonate is the main extracellular buffer maintaining blood pH, clinically used to treat severe metabolic acidosis and hyperkalemia, but must be used cautiously due to risks of alkalosis and sodium overload
Resources: High protein, low glycaemic index portion plate High protein, low glycaemic index portion plate EAT FIRST: Protein EAT SECOND: Vegetables / salad EAT LAST: LGI carbohydrates Reading food labels to work out the carbohydrate content in foods Reading food labels to work out the carbohydrate content in foods When reading the information on food labels the nutritional information is often given per 100 grams of food
Based on the amount of GSH in the lysate, we calculated the GSH concentration assuming an averaged HeLa cell volume of 4,000 m 3 (refs 15, 51, 52)
MB Liquid L-Carnitine is made from Carnipure- a special grade of L-Carnitine, sourced from Switzerland for a superior shredding advantage
