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N Engl J Med (1984) 311(22):14037.10.1056/NEJM198411293112203 200 VahlNJorgensenJOJurikAGChristiansenJS

However, as we discussed DAM and DAA, it remains largely unclear how reactive astrocytes, which originate from the neuroectoderm, acquire functional similarities, such as inflammatory responses and phagocytic activity, to immune cells like microglia and macrophages that arise from primitive hematopoietic progenitors and mesoderm-derived bone marrow hematopoietic cells

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Large-scale data like this reinforce the emerging idea that GLP-1 receptor agonists may influence brain reward pathways, not just metabolism