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Researchers who experience unusual injection site reactions or side effects not consistent with published trial data should consider purity as a potential culprit

These discrepancies may reflect species-specific differences that include the relative accessibility and importance of GLP-1R circuits in the CNS compared with those in the peripheral nervous system for controlling appetite, or these discrepancies may be due to other limitations, including the dose, potency, pharmacokinetics, and selectivity of the antagonist used and the short-term observation period

You can stay at the lower dose longer if you need time to adjust