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Severe cases of homocystinuria are typically caused by autosomal recessive genetic defects and exhibit characteristic clinical features including ocular lens dislocation, marfanoid features and other skeletal abnormalities including osteoporosis, intellectual disability, and thromboembolic disease, the latter frequently being the cause of premature death in affected individuals (28)

This high demand is behind nationwide shortages that have been happening since 2022 and are expected to last throughout 2024

Global impacts of western diet and its effects on metabolism and health: a narrative review