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8 % of those assigned to placebo) and for improvement in liver fibrosis (45 % vs

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however, blocking IL-12 may not be necessary

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Inclusion criteria included RCTs that evaluated GLP-1RAs or tirzepatide in adults with T2D and established ASCVD or high CV risk (including CKD), and reported the following outcomes: MACE, CV mortality, all-cause mortality, non-fatal myocardial infarction (MI), or non-fatal stroke

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