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In the brain, most of the zinc ion is tightly bound to proteins, but free zinc is present in synaptic vesicles and has a role in neurotransmission mediated by glutamate and GABA (76)

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Similar results were observed when rodents were exposed to prolonged hypoxia, showing increased angiogenesis that was later normalized in a normoxic environment ( 1 -R are involved in neovascularization in differents animals models of angiogenesis