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Description

It downregulates ten-eleven-translocation protein 3 (TET3) and impairs the DNA demethylation at the paternal alleles of several insulin secretion genes such as glucokinase (GCK), thus making the offspring susceptible to impaired glucose tolerance and diabetes

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Other side effects are fatigue, a little joint achyness , and sore arm at injection site (which is better now)

When removing the thionitrobenzoic acid group by reduction and restoring the free cysteine, reactivity with MBP-SpyTag002 was fully restored for all 8 mutants (Fig