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28 Loperamide is pregnancy category B, and its use in pregnancy has not been associated with major malformations

But also risky

Recently, newer options have been more successful in individuals with a BMI 30 kg/m 2 or 27 kg/m 2 with obesity-related comorbidities such as type 2 diabetes, high blood pressure, high cholesterol or obstructive sleep apnea

Wadden and colleagues assessed changes in depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9) and suicidal ideation or behaviors using the Columbia Suicide Severity Rating Scale in participants with overweight or obesity using semaglutide 2.4 mg or placebo