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For this reason, the homeostasis of extracellular glutamate is tightly controlled by the combined activity of neuronal and glial membrane transporters, such as glutamate transporter-1 (GLT1), glutamate aspartate transporter (GLAST), and the cysteine/glutamate antiporter, or system xc (Sxc ), present in astrocytes, and EAAT3 present in neurons

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Weight and thyroid function : Weight loss itself may influence levothyroxine requirements, as dosing is partly weight-dependent

The British Society of Gastroenterology recommends testing for bile acid diarrhoea in anyone with persistent undiagnosed chronic diarrhoea, using either a SeHCAT scan or a blood test for 7-hydroxy-4-cholesten-3-one (known as C4)