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Notwithstanding the temporary measures implemented in response to the PHE for COVID-19 and extended thereafter, direct supervision has historically required the physician (or other supervising practitioner) to be present in the office suite and immediately available to furnish assistance and direction throughout the performance of the service

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We investigate a particular aspect of the sudden onset of encephalopathy with paracetamol overdose (for review see 1-3) so far not reported: may paracetamol rapidly induce hepatic encephalopathy with generalized convulsions in rats and if so, the possible therapy effect in early and advanced stage