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Finally, individuals with a history of heart failure, ischaemic heart disease, unstable angina, myocardial infarction, aortic aneurysm or dissection, stroke (ischaemic or haemorrhagic stroke), cerebral infarction, transient ischaemic attack, carotid intervention or surgery, coronary stenting, percutaneous coronary intervention (PCI) or coronary artery bypass before inclusion to the cohort or prior to the index event were also excluded

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Participants Adults (18 years old) with 1 or more self-reported unsuccessful dietary weight loss efforts and a body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) of 30 or greater or 27 or greater with 1 or more weight-related comorbidities (hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease) were eligible (eAppendix 1 in Supplement 3)

According to a study, the elimination half-life of Diphenhydramine increases when the dose is increased