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The risk appears to be higher at larger doses, which correlates with greater weight loss, though a direct dose-response relationship has not been definitively established

Here is the breakdown by dose group from the trial: 4 mg dose group: average weight loss of 8.7% 8 mg dose group: average weight loss of 17.3% 12 mg dose group: average weight loss of 24.2% Placebo group: average weight loss of 2.1% The 12 mg group also showed that 26% of participants lost 30% or more of their body weight

Cell-specific transport and thyroid hormone receptor isoform selectivity account for hepatocyte-targeted thyromimetic action of MGL-3196

Alcohol can worsen common side effects such as nausea, interfere with blood sugar regulation, and undermine weight loss progress