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Consumers should be aware that marketing claims often exceed the available scientific evidence, and there is currently no official recognition of transdermal berberine as an effective delivery method by regulatory or clinical authorities

At week 112, the full-dose group remained down 22.4% from baseline, while the 5 mg group remained down 17.0%

The finding of disrupted selenium metabolism in patients suggests a potential feed-forward cycle of pharmacological treatment, oxidative stress, renal damage and impaired selenoprotein expression