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Conclusion and perspectives In conclusion, ASD is a complex disease caused by a series of combinations of different aetiological factors, including genetic factors, environmental and immune activation, etc., and ultimately manifests as abnormal changes in molecular signalling pathways, neuronal synapses, immune environment and brain functional connections

DSIP at an injected dose of 30mcg/kg has been shown to influence the circadian rhythm of rats, resulting in decreased activity after dark and increased activity during light hours