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25-39% The estimated proportion of weight lost on GLP-1 therapy that may come from lean mass rather than fat, based on body composition analyses from clinical trial data. The precise figure varies by patient, dose, and whether resistance exercise is incorporated

Higher maintenance doses were generally linked with greater weight loss, especially when patients stayed on treatment for longer

Regarding thyroid safety: animal studies with GLP-1 receptor agonists have identified thyroid C-cell changes in rodents

How it Works: It improves insulin sensitivity and signals the brain to significantly reduce hunger while slowing digestion