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Since PAI-1 exists in significant excess relative to tissue plasminogen activator (tPA) in plasma, even modest reductions could meaningfully improve the body ability to clear clots

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These processes can disrupt the blood-brain barrier, allowing inflammatory factors to enter the CNS and subsequently activate neuroglia through various signaling pathways such as NF-B and cholinergic mechanisms, ultimately promoting the development of depression ( A variety of herbal compounds, monotherapies, and their active ingredients have demonstrated remarkable efficacy in reducing depression symptoms with minimal side effects when utilizing traditional herbal treatments (Shao et al., 2022)