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Global analysis of the mitochondrial proteome in response to cellular GSH depletion To identify mitochondrial proteins regulated by GSH availability, we used quantitative proteomics and analyzed mitochondria immunopurified from HeLa cells expressing a mitotag (3XHA-OMP25-mCherry) grown in standard media or treated with the glutathione synthesis inhibitor, buthionine sulfoximine (BSO) 13

Symptoms included persistent diarrhea, stomach pain and weight loss, often requiring intensive care and immune-suppressing drugs

Ozempic (semaglutide), a GLP-1 receptor agonist, is a prescription medication most commonly used to manage blood sugar levels in people with Type 2 diabetes