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At the 12-month follow-up : 87.5% of patients reported significant relief defined as 50% reduction in baseline pain scores Mean VAS pain score dropped from 7.2 at baseline to 2.8 at 12 months KOOS (Knee Injury and Osteoarthritis Outcome Score) improved across all subscales: pain, symptoms, activities of daily living, sport/recreation, and quality of life No serious adverse events were reported across the treatment period The durability of the response at 12 months is particularly notable

doi:10.1002/nop2.377 [cited 2021 Nov 24] 33

Laboratory investigations have explored its interactions with hypothalamic and limbic receptor systems, as well as its potential modulatory effects on stress hormone pathways in preclinical settings

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