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however, individuals already taking glucose-lowering medicines (including insulin) may be at increased risk of hypoglycaemia if GH-mediated effects alter their insulin sensitivity Injection site reactions, including pain, redness, and infection risk For retatrutide , the side effect profile observed in clinical trials is consistent with that of other GLP-1 receptor agonists and includes nausea, vomiting, diarrhoea, and constipation