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The natural compound T1 isolated from Gastrodia elata shows outstanding inhibitory potency against tyrosinase (IC 50 = 0.53 M, K i = 58 6 nM), which is more effective than -arbutin, kojic acid, short peptides 74,75 and other known natural compounds (Supplementary Table S1)

Lowers a signaling protein (TGF-1) and reduces cell stress (measured by an antioxidant enzyme called SOD), both of which contribute to hair follicles shrinking due to the hormone DHT

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Higher IV doses may be diluted in saline in a clinical setting