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Neurodegenerative diseases are characterized by the slow, progressive loss of neuronal cells in the central nervous system (CNS) and the aggregation of misfolded proteins (Cenini et al., 2020)

Taking this into account, current regulations stipulate that preclinical testing should include higher drug doses than those expected to be encountered by patients [77].The failure of the medical community to accurately track APAP use in the pediatric population over time as well as its almost ubiquitous use identified in some studies (Fig