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Semaglutide As the OG of GLP-1 agonists, semaglutide's Ozempic iteration took the world by storm in the early 2020s, leading to phrases like the "Ozempic Era." FDA-approved for type 2 diabetes Also approved to reduce the risk of heart attack, stroke, and cardiovascular death in adults with type 2 diabetes and heart disease Approved in 2024 to help protect against kidney disease progression in people with type 2 diabetes and chronic kidney disease FDA-approved for chronic weight management in adults and teens 12+ Also approved to reduce the risk of heart attack, stroke, and cardiovascular death in adults with obesity and heart disease, even without diabetes Oral version of semaglutide Approved for type 2 diabetes Tirzepatide Tirzepatide first entered the public spotlight in May 2022 when the U.S

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Tirzepatides additional GIP receptor activity makes it distinct from Trulicity and may contribute to its enhanced effects on weight loss and metabolic health