When protein intake is insufficient, the body may break down muscle tissue for energy, which can result in: Weakened muscles and reduced strength A slower metabolism, making calorie burning less efficient An increased risk of regaining weight after stopping the medication Additionally, research suggests that GLP-1 therapy decreases muscle protein synthesis, meaning the body has a harder time rebuilding lost muscle
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Illustratively, the assessment included the morphologic features of mucosal injury (i.e., different grades of epithelial lifting, villi denudation, and necrosis), inflammation (i.e., focal to diffuse, according to lamina propria infiltration or subendothelial infiltration), and hyperemia/hemorrhage (i.e., focal to diffuse, according to lamina propria or subendothelial localization)
However, these side effects werent confirmed to be associated with the treatment and could have been a coincidence and not related to the use of retatrutide